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M9460176.TXT
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1994-06-12
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Document 0176
DOCN M9460176
TI HIV vaccine trials: will intravenous drug users enroll?
DT 9408
AU Meyers K; Metzger DS; Navaline H; Woody GE; McLellan AT; Center for
Studies of Addiction, University of; Pennsylvania/Philadelphia
Department of Veterans Affairs 19104.
SO Am J Public Health. 1994 May;84(5):761-6. Unique Identifier : AIDSLINE
MED/94234404
AB OBJECTIVES. The purpose of this study was to assess the willingness of
intravenous drug users to participate in a preventive human
immunodeficiency virus (HIV) vaccine efficacy trial. METHODS. Of the 347
intravenous drug users in methadone treatment who were approached for
participation, 257 completed a battery of self-administered
questionnaires assessing risk behaviors, interest in vaccine trials, and
other vaccine-related information. Data from 16 known seropositives and
1 inconsistent responder were dropped from analyses (n = 240). RESULTS.
Fifty-two percent of the subjects expressed a willingness to be one of
the first individuals to participate in a preventive HIV vaccine
efficacy trial. Subjects who had recently shared needles or works and
subjects who trusted the government to ensure vaccine safety were both
twice as likely to report interest in participation. Twenty-two percent
of subjects reported that they would increase needle sharing if
vaccinated. Thirty percent did not know what a vaccine was. CONCLUSIONS.
These findings suggest that some in-treatment intravenous drug users
would volunteer for a preventive HIV vaccine efficacy trial. Education
and counseling will be required to ensure that subjects fully understand
the trial's purposes, methods, risks and benefits.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PREVENTION & CONTROL
Adult *AIDS Vaccines *Clinical Trials Female Human Logistic Models
Male Middle Age *Patient Acceptance of Health Care *Substance Abuse,
Intravenous/COMPLICATIONS/PSYCHOLOGY Support, U.S. Gov't, P.H.S.
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).